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Retno Pudji Rahayu
Department Of Oral Pathology And Maxillofacial, Faculty Of Dental Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Chemistry

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ANALYSIS OF IFN-γ CONCENTRATION IN WISTAR RAT BLOOD AFTER ORAL ADMINISTRATION OF STANDARDIZED GREEN TEA WATER EXTRACT Djoko Agus Purwanto; Retno Pudji Rahayu; A. Toto Purnomo
Indonesian Journal of Chemistry Vol 10, No 3 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.094 KB) | DOI: 10.22146/ijc.21448

Abstract

Green tea and its polyphenols have been studied extensively as cancer chemopreventive agents in recent years. However, the mechanisms of action are still not clearly understood. Some researchers suggest that immune system plays important role to destroy cancer cells. Because of that reason, the present study was designed to analyse the effects of oral administration standardized green tea water extract on increasing of IFN-g blood concentration and to elucidate possible mechanisms involved in the inhibitory action of the cancer development. Two groups (male and female) of 5 rats have given p.o. administration 1.25% of standardized green tea water extract and got 300 mg of (-)-epigallocatechin gallate (EGCG)/kg body weight, while two groups others (male and female) were used as control. We found that IFN-g blood concentration on male and female Wistar rat are significantly increase with 13.11% and 17.59%, respectively (p<0.05) by ELISA method, whereas control had no increase. These results indicate that standardized green tea water extract has possibility to prevent and suppress cancer development through enhancing IFN-g expression and other immunosurveillance component.
Co-Authors A. Toto Purnomo Achmad Ardianto Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Agung Sosiawan Aisah Faiz Bachmid Aqsa Sjuhada Oki Ardyni Febri K Azhar, Imam Safari Bimo Dwi Lukito Bimo Dwi Lukito, Bimo Dwi Budi Utomo Budi Utomo Chaterina Dyah Nanik Kusumawardani Christian Khoswanto, Christian Dewi Puspitasari Dewi Puspitasari Diah Savitri Ernawati Dian Widya Damaiyanti Djoko Agus Purwanto Eha Djulaeha Elly Munadziroh Fatimah F. Basalamah Fedik Abdul Rantam Ferdiansyah Ferdiansyah Ferdiansyah Ferdiansyah Hansen Kurniawan Haryono Utomo I Ketut Sudiana Ira Arundina Juniastuti Juniastuti Juniastuti Juniastuti Kharinna Widowati M. Qushay M. Qushay, M. Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maharani Laillyza Apriasari Maretaningtias Dwi Ariani, Maretaningtias Dwi Maria Inge Lusida Maria Inge Lusida Moch Febi Alviansyah Muhammad Luthfi Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nasronudin Nurina Febriyanti Ayuningtyas Prihartini Widiyanti Puspa Dila Rohmaniar Regina Purnama Dewi Iskandar Retno Indrawati Roestamadji Saka Winias sari, Rima parwati Selviana R. Pramitha Siti Qamariyah Khairunisa Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa Siti Qomariyah Khairunisa, Siti Qomariyah Sri Agoes Soedjarwo Sri Hernawati Surboyo, Meircurius Dwi Condro Syamsulina Revianti Titiek Berniyanti Togu Andrie S. Pasaribu Tomohiro Kotaki Tomohiro Kotaki Tomohiro Kotaki, Tomohiro Utari Kresnoadi Wahyu Aji Wibowo Widyasri Prananingrum Wirza, Yanty